DEVELOPING INNOVATIVE THERAPEUTICS THAT TARGET AND MITIGATE THE UNDERLYING MECHANISMS OF INFLAMMATION AND OXIDATIVE STRESS
Inflammation and oxidative stress play crucial roles in the development of several chronic conditions such as neurodegenerative and cardiovascular diseases, diabetes, cancer and more. These mechanisms are interconnected, with the potential to intensify one another, thus fueling a cycle that significantly accelerates the progression of these diseases. Our proprietary ISM (Isotope-Selective Modulation) technology is at the forefront of developing innovative treatments, leveraging our deep insights into the behavior of metal atoms within biological systems.
The metallome is intricately connected to other "omes" such as the genome, proteome, microbiome, and more, influencing and being influenced by those biological systems through its role in essential metal ion regulation and interactions.
The metallome encompasses the distribution of metal ions within tissues and celles, and is critical for a myriad of biological processes, including the synthesis of amino acids and proteins, maintaining charge balance and electrolyte function, ensuring DNA integrity and facilitating its repair, as well as playing a key role in structure, signaling, and stem cell functionality. Our drug candidates are designed to stimulate the fundamental biological activities of the metallome to re-establish a state of healthy homeostasis.
Our primary expertise is centered around the integration of metallomics and pharmaceutical development, focusing on the role and function of stable light isotope ratios within metalloproteomics.
We are pioneering the field of Metallomics for over a decade, offering a unique scientific approach to understanding disease origins. Our research goes beyond molecular patterns to examine isotopic signatures at the atomic level in cells and tissues, contributing to the study of metalloproteomics.
Our research shows that healthy cells and tissues feature light isotope signatures, while malignant cells and tissues feature heavy isotope signatures
Heavy isotopes, when present in higher concentrations, can disrupt cellular functions and contribute to local and systemic inflammation and oxidative stress - two well-known harbingers of many diseases. Our isotope-selective modulation approach explores how metal isotopes impact biological functions and disease processes. By utilizing light cold isotopes, we are developing safe and effective drugs that engage multiple pathways for enhanced therapeutic outcomes in treating complex diseases and can be used in patients with chronic illnesses.
Unlike conventional medications that typically interact with their targets on a surface level, thereby managing symptoms rather than the root cause, our isotope-selective modulation, in conjunction with a multi-omic approach, empowers us to create drugs that holistically influence critical biological processes, ranging from protein synthesis and DNA repair to mitochondrial function, and reduction of local any systemic inflammation and oxidative stress.
Unhealthy aging, coupled with exposure to dietary and environmental factors hazards, can exacerbate the imbalance of metal isotopes, which becomes a driving force in a progress of pathology.
The medical use of stable light isotopes in various therapies is pivotal for their ability to cross the blood-brain barrier, enabling direct engagement with metalloproteins and cellular processes. The inherent safety profile of stable light isotopes in metallome highlights its transformative potential in the development of novel pharmaceuticals, hence, promising new era of treatments that are both more effective and clinically safe.
Metallomics is a multidisciplinary science that merges the fields of chemistry, biology, physics, and medicine to explore the functions of metals in biological contexts. It delves into the metallome, which encompasses the entire range of metals present within cells and organisms. Utilizing sophisticated mass spectrometry techniques, we investigate the concentrations, distributions, and interactions of these metals. The study of the isotope signatures of the metallome is essential for deciphering the etiology of the diseases associated with metal imbalances, which are often linked to chronic inflammation and oxidative stress, and for probing the basic mechanisms underlying vital life processes.
Metallomix is leveraging cutting-edge science to develop new therapies that address critical gaps in treatment of metabolic disorders and neurological conditions, ensuring clinically de-risked development and streamlined regulatory approval pathways.
Metallomix is leveraging cutting-edge science to develop new therapies that address critical gaps in treatment of metabolic disorders and neurological conditions, ensuring clinically de-risked development and streamlined regulatory approval pathways.
Guided by our founders' proven track record in establishing successful enterprises, we have built a team of seasoned, mission-focused specialists who enhance our innovative approach and share our commitment to making a positive impact. We consistently explore and assess a broad range of available resources to support our business expansion and strengthen our operations.
Founder, President & CSO
Chemistry & Business
Co-Founder & CEO
Biotech & Venture Capital
Co-Founder & CMO
Medicine & Molecular Biology
Co-Founder, VP & CFO
Nuclear Physics & Finance
175 Southwest 7th Street, Miami, Florida 33130, United States
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